Titelbild: Heterochromia in Designed Metallopeptides: Geometry-Selective Binding of CdII in a De Novo Peptide (Angew. Chem. 35/2007)
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منابع مشابه
Heterochromia in designed metallopeptides: geometry-selective binding of CdII in a de novo peptide.
One of the most important chemical concepts is defining how one molecule recognizes and controls the properties of another molecule or ion. Nowhere is this issue more significant than in the field of biomolecular recognition. Metalloproteins efficiently control the geometry and coordination number of metal ions as well as the types of ligands bound to them. Incorporation of metals in the correc...
متن کاملHeterochromia in Designed Metallopeptides: Geometry-Selective Binding of Cd in a De Novo Peptide**
One of the most important chemical concepts is defining how one molecule recognizes and controls the properties of another molecule or ion. Nowhere is this issue more significant than in the field of biomolecular recognition. Metalloproteins efficiently control the geometry and coordination number of metal ions as well as the types of ligands bound to them. Incorporation of metals in the correc...
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The structural characterization of de novo designed metalloproteins together with determination of chemical reactivity can provide a detailed understanding of the relationship between protein structure and functional properties. Toward this goal, we have prepared a series of cyclic peptides that bind to water-soluble metalloporphyrins (FeIII and CoIII). Neutral and positively charged histidine-...
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Metal-binding studies for a de novo designed calcium-binding protein.
To understand the key determinants in calcium-binding affinity, a calcium-binding site with pentagonal bipyramid geometry was designed into a non-calcium-binding protein, domain 1 of CD2. This metal-binding protein has five mutations with a net charge in the coordination sphere of -5 and is termed DEEEE. Fluorescence resonance energy transfer was used to determine the metal-binding affinity of ...
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2007
ISSN: 0044-8249,1521-3757
DOI: 10.1002/ange.200790171